Signal Transduction and Communication in Cancer Cells (Annals of the New York Academy of Sciences)



Publisher: New York Academy of Sciences

Written in English
Published: Pages: 499 Downloads: 344
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Subjects:

  • Life Sciences - Biology - Molecular Biology,
  • Genetics,
  • Immunology,
  • Oncology,
  • Medical,
  • Science

Edition Notes

ContributionsH. Leon Bradlow (Editor), Luigi Castagnetta (Editor), Luisa Massimo (Editor), Kurt Zaenker (Editor)
The Physical Object
FormatHardcover
Number of Pages499
ID Numbers
Open LibraryOL12228654M
ISBN 101573315591
ISBN 109781573315593

Cell signal transduction therapy seeks to regulate the signaling pathways in cancer cells to make them easier to control or kill. One most effective way to trip up cancer is to use nutrients, phytochemicals (natural plant-derived chemicals), and drugs to suppress overactive signal transduction pathways, or boost under-active pathways, in cancer. Cellular communication is an umbrella term used in biology and more in depth in biophysics, biochemistry and biosemiotics to identify different types of communication methods between living cellulites. Some of the methods include cell signaling among others. This process allows millions of cells to communicate and work together to perform important bodily processes that are necessary for survival. Cell subtypes in human breast cancer and the alterations in calcium homeostasis. The mammary gland is an exocrine, compound tubuloalveolar gland [].Each mammary gland has 15–20 glandular lobes in its structure, each lobe being a separate gland with its excretory channel (galactophore channel) that opens at the level of the nipple via the galactophore pore [].   C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Factor (HGF) which is secreted among others by mesenchymal stroma/stem (MSC) cells. Physiological c-Met functions are centred around processes that underly cellular motility .

In the present study, we measure the levels of GH and GH receptor (GHR) mRNA in multiple prostate cancer and normal prostate-derived cell lines, and compare the effects of exogenous and autocrine GH on LNCaP prostate cancer cell proliferation and apoptosis, and the associated signal transduction .   SIGNAL TRANSDUCTION Any process occurring within cells that convert one kind of signal/stimulus into another type. It also known as cell signaling in which the transmission of molecular signals from a cell's exterior to its interior. Signals received by cells must be transmitted effectively into the cell to ensure an appropriate response. Exosomes (EXs), a type of extracellular vesicles secreted from various cells and especially cancer cells, mesenchymal cells, macrophages and other cells in the tumor microenvironment (TME), are involved in biologically malignant behaviors of cancers. Recent studies have revealed that EXs contain microRNAs on their inside and express proteins and glycolipids on their outsides, every component. In biology, cell signaling (cell signalling in British English) or cell-cell communication, governs the basic activities of cells and coordinates multiple-cell actions. A signal is an entity that codes or conveys ical processes are complex molecular interactions that involve a lot of signals. The ability of cells to perceive and correctly respond to their microenvironment is.

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as Price: $ g protein coupled receptors methods in signal transduction series Posted By Michael Crichton Publishing TEXT ID be49 Online PDF Ebook Epub Library methods in signal transduction series sep 07 posted by seiichi morimura publishing text id ddb7c online pdf ebook epub library coupled receptors gpcrs also.

Signal Transduction and Communication in Cancer Cells (Annals of the New York Academy of Sciences) Download PDF EPUB FB2

Signal Transduction and Communication in Cancer Cells (Annals of the New York Academy of Sciences): Medicine & Health Science Books @   Signal transduction and communication in cancer cells. [and others] -- Phase I trial on once-weekly sms-D70 somatostatin analogue in advanced prostate and renal cell cancer / by T.K.

Joensuu [and others] -- Interaction between the immune system and tumor cells / by M. Laimer, C.M. Lanschuetzer, and H. Hintner -- Secretory leukocyte protease Pages:   Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment.

When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may. Signal transduction and communication in cancer cells. New York, N.Y.: New York Academy of Sciences, (DLC) Material Type: Conference publication, Document, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: H Leon Bradlow; New York Academy of Sciences.

Click on the title to browse this issue. The Cellular Communication in Cancer Program explores the molecular signals within and between cells that drive cancer. Researchers in this Program are developing innovative new models for human tumors and advanced imaging technology with a goal of identifying potential “druggable” targets and mechanisms of drug resistance in cancer.

Abstract. There are many different signaling pathways that contribute to development and cellular homeostasis. In diseases, especially cancer, development components of these pathways often become mutated or overexpressed causing dysregulation of cellular signaling.

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics.

Suppression of these exaggerated signals may be one way to reduce cell proliferation in cancer. Purpose of Signal Transduction. Signal amplification • increasing a signal so that minimal receptor occupation by small amounts of neurotransmitters in the synapse produces significant cellular responses.

The Importance of Good Communication: Cell Signaling and How it Relates to Cancer. Inthe United States Congress declared May as Cancer Research Month.

We know that supporting cancer research is important, ultimately leading to earlier detection, better treatments, possibly even a cure.

Cancer is a complex disease caused by genetic and/or epigenetic changes in one cell or a group of cells. These alterations disrupt ‘normal’ cell function and cause cancerous cells to over proliferate and avoid mechanisms that would typically control their growth, division, and migration.

1,2 Many of these ‘disruptions’ map to specific cell signaling pathways. A signal is detected when the chemical signal (also known as a ligand) binds to a receptor protein on the surface of the cell or inside the cell.

Transduction: When the signaling molecule binds the receptor it changes the receptor protein in some way. This change initiates the process of transduction. Signal transduction is usually a pathway. Home > Research > Signal Transduction. Signal Transduction "The intracellular transfer of information (biological activation/inhibition) through a signal pathway.

In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel.

Introduction. Cell signal transduction refers to the binding of extracellular factors to a receptor (membrane receptor or nuclear receptor), triggering a series of biochemical reactions and protein interactions in the cell, until the genes which required for cellular physiological reactions begin to express and the process of forming biological effects.

Porquet N., Huot J. () Signal Transduction in Tumor-Endothelial Cell Communication. In: Brodt P. (eds) Liver Metastasis: Biology and Clinical Management. Cancer Metastasis. In the communication between cells of an organism, the signals (messengers such as hormones) are produced in specialized cells.

The signal-producing function of these cells is itself regulated, so that the signal is only produced upon a particular stimulus. In this way signaling pathways can be coupled to one another and coordi-nated. Lecture I: Growth Factors and Receptors What is Signal Transduction.

Signal Transduction is the process by which a cell converts an extracellular signal into a response. Involved in: Cell-cell communication Cell’s response to environment Intracellular homeostatsis- internal communication 3.

The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.

Underlying these is a dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer. This affects not only the cancer cells themselves, but the wider signaling network that encompasses other cells, the ECM, blood vessels, and the immune system.

Applications that focus on signal transduction or metabolism in cancer cells and tumors may be assigned to TCB. There are shared interests with Cellular Signaling and Regulatory Systems [CSRS] in the investigation of signaling pathways, post-translational modifications and cell cycle. In its broadest context, cell signaling involves the transduction of some event into another event.

In sensory transduction, a sensory cell is exposed to some external signal that is transduced to produce a nervous signal, the action potential. As we will see later in Chapterthis action potential can move along cell membranes to rapidly convey the signal, the action potential, to remote.

Some cells either make too many HER receptors, which makes the receptors hyper-reactive to growth factors or the HER receptors are always activated, even without the presence of a growth factor. Both instances cause too many of the cells divide, causing abnormal growth of cells in the body.

This communication can lead to non-targeted effects, where non-treated or non-infected cells show effects induced by signal transduction from non-healthy cells or vice versa. In the last 15 years, tunneling nanotubes (TNTs) were identified as membrane connections between cells which facilitate the transfer of several cargoes and signals.

The cell then carries out the instructions encoded in the signal. In a given day, the body's cells send and receive billions of signals. In some cancer cells, the signals sent to regulate growth or initiate apoptosis get short-circuited, resulting in rapid cell growth that may lead to tumors.

21 Signal Transduction in Cancer, Richard Sever and Joan S. Brugge 22 Outlook, This book was conceived and organized as an instructional resource area to the underlying foundations and basic mechanisms of signal transduction in animal cells. Such a volume is needed because signaling impinges on every aspect of.

Advances in Cancer Signal Transduction and Therapy covers advancements in research on the signaling pathways in the human body, especially in some types of cancers, such as breast cancer.

References: Wilson CW, Chuang PT () Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (13), –; Young RA () Control of the embryonic stem cell state. Cell (6), –; Ng HH, Surani MA () The transcriptional and signalling networks of pluripotency.

Nat. Cell Biol. 13(5), –6. Miki T, Yasuda SY, Kahn M () Wnt/β-catenin signaling. Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting through a receptor located in the membrane of target cells - major ones being liver (where it promotes glucose storage into glycogen and decreases glucose output), as well as skeletal muscle and fat (where it stimulates glucose transport through translocation of GLUT4), but also b cells, brain cells and in.

Breast cancer is the cancer with the highest prevalence in women and is the number-one cause of cancer mortality worldwide. Cell transduction is a fundamental process in the development and progression of cancer. Modifications in various cell signalling pathways promote tumour cell proliferation, progression, and survival.

The PI3K/Akt/mTOR pathway is an example of that, and it is involved in. Manipulation and detection of survival signals --Functional analysis of the antimitogenic activity of tumor supressors / Erik S. Knudsen --Rescue and isolation of Rb-deficient prostate epithelium by tissue recombination / Simon W.

Hayward --Signal transduction study using gene-targeted embryonic stem cells / Hideki Kawasome --The use of the. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation.

The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells.In this review we discuss recent findings on how signal transduction is tuned in the Notch pathway and how Notch signaling is dysregulated in disease.

We also discuss different strategies to modulate Notch signaling for clinical use, for example by novel antibody-based tools and by taking advantage of the cross-talk between Notch and other.

Methods Signal transduction pathway activity scores were measured on Affymetrix expression microarray data of resting, immune-activated, and immune-activated CD4+ T cells incubated with breast cancer tissue supernatants, and of CD4+ Th1, Th2, and Treg cells, and in a clinical study in which CD4+ T cells were derived from blood, lymph node and cancer tissue from primary breast cancer .